Anti-ADAM15 Antibody

Cat: 51001-RP02

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Anti-ADAM15 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-ADAM15 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse ADAM15
Immunogen
Recombinant Mouse ADAM15 protein (Catalog#51001-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse ADAM15 (rM ADAM15; Catalog#51001-M08H; O88839-1; Met 1-Thr 697). ADAM15 specific IgG was purified by Mouse ADAM15 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Anti-ADAM15 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ADAM15 Antibody Alternative Names

Anti-MDC15 Antibody;Anti-metargidin Antibody

ADAM15 Background Information

ADAM15, also known as Metargidin, is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain) family of proteins and is widely expressed in different tissues and cell types. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of ADAM15/metargidin contains an RGD tripeptide sequence, suggesting that it may potentially interact with the integrin family of proteins. ADAM15 is a transmembrane multi-domain proteins implicated in proteolysis, cell-cell and cell-matrix interactions in various disease conditions. There is also evidence supporting a role for ADAM15 in angiogenesis and angioinvasion of tumor cells, which are critical for unrestrained tumor growth and metastatic spread. Given its diverse functions, ADAM15 may represent a pivotal regulatory component of tumor progression, an important target for therapeutic intervention, or emerge as a biomarker of disease progression.
Full Name
ADAM metallopeptidase domain 15
References
  • Poghosyan Z, et al. (2002) Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. J Biol Chem. 277(7): 4999-5007.
  • Carl-McGrath S, et al. (2005) The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer. Int J Oncol. 26(1): 17-24.
  • Najy AJ, et al. (2008) ADAM15 supports prostate cancer metastasis by modulating tumor cell-endothelial cell interaction. Cancer Res. 68(4): 1092-9.
  • Maretzky T, et al. (2009) Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. Biochem J. 420(1): 105-13.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ADAM15 Antibody Rabbit Monoclonal ELISA 51001-R001
    Anti-ADAM15 Antibody Rabbit Polyclonal ELISA 51001-T16
    Anti-ADAM15 Antibody Rabbit Polyclonal ELISA 51001-RP01
    Anti-ADAM15 Antibody Rabbit Polyclonal ELISA 10517-RP02
    Anti-ADAM15 Antibody (FITC) Mouse Monoclonal FCM 10517-MM11-F
    Anti-ADAM15 Antibody Rabbit Monoclonal ELISA(Cap) 10517-R027
    Anti-ADAM15 Antibody Rabbit Polyclonal ELISA 10517-RP01
    Anti-ADAM15 Antibody Mouse Monoclonal ELISA,FCM 10517-MM11
    Anti-ADAM15 Antibody (APC) Mouse Monoclonal FCM 10517-MM11-A
    Anti-ADAM15 Antibody (PE) Mouse Monoclonal FCM 10517-MM11-P
    Anti-ADAM15 Antibody Rabbit Monoclonal ELISA,ELISA(Det),IHC-P,FCM,ICC/IF,IF 10517-R007
    Anti-ADAM15 Antibody (APC) Rabbit Monoclonal FCM 10517-R007-A
    Anti-ADAM15 Antibody (PE) Rabbit Monoclonal FCM 10517-R007-P
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