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B18R/Vaccinia Virus B18R  Protéine

All B18R Reagents

Hôte d’expression: Baculovirus-Insect Cells  
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40020-V08B-10
40020-V08B-20
10 µg 
20 µg 
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B18R/Vaccinia Virus B18R Voies apparentées

B18R/Vaccinia Virus B18R Récapitulatif et informations sur les protéines

B18R/Vaccinia Virus B18R Fond

B18R is a type I interferon (IFN)-binding protein, which is encoded by the B18R open reading frame in the WR (Western Reserve)strain of vaccinia virus. It is also known as B19R in the Copenhagen strain of Vaccinia. B18R exists in a soluble and a membrane-bound form. As a type I IFN receptor, B18R has a broad species specificity. It has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. It has been shown that secreted B18R binds to uninfected and infected cells. It presents at the cell surface and protects cells from the antiviral state induced by IFN-alpha and IFN-beta. Binding of soluble recombinant B18R protects cultured cells from IFN and allows vaccinia virus replication.

B18R/Vaccinia Virus B18R Autre dénomination

CD317,TETHERIN, [homo-sapiens]
VACWR199, [Vaccinia virus]

B18R/Vaccinia Virus B18R Études apparentées

  1. I Vancov. et al., 1998, J Gen Virol July. 79 (7): 1647-9.
  2. Colamonici OR. et al., 1995, J Biol Chem. 270 (27): 15974-8.
  3. Goebel SJ. et al., 1990, Virology 179: 247-66.
  4. Goebel SJ. et al., 2010, J Cell Biol. 190 (4): 533-9.
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