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BTLA  Protéine

All BTLA Reagents

Hôte d’expression: Human Cells  
  • Slide 1
11895-H02H-50
11895-H02H-100
50 µg 
100 µg 
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Hôte d’expression: Human Cells  
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51060-M02H-50
51060-M02H-100
50 µg 
100 µg 
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Hôte d’expression: Human Cells  
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81142-R05H-50
81142-R05H-100
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100 µg 
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Hôte d’expression: Human Cells  
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90250-C02H-50
90250-C02H-100
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100 µg 
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BTLA Voies apparentées

BTLA Récapitulatif et informations sur les protéines

BTLA Fond

Résumé du gène: BTLA gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in BTLA gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]
General information above from NCBI
Structure de sous-unités: Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM.
Localisation subcellulaire: Membrane; Single-pass type I membrane protein (Potential).
Post-traductionnel: Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.
N-glycosylated.
Similarité de séquence: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
General information above from UniProt

BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).

BTLA Autre dénomination

BTLA1,CD272, [homo-sapiens]
B and T lymphocyte attenuator,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein,BTLA1,CD272, [human]
A630002H24,B and T lymphocyte attenuator,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein, [mouse]
A630002H24, [mus-musculus]

BTLA Études apparentées

  • Fourcade J, et al. (2012) CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res. 72(4):887-96.
  • Kojima R, et al. (2011) Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT. J Mol Biol. 413(4):762-72.
  • Oki M, et al. (2011) A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis. Clin Dev Immunol. 305656.
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