BTN2A2 (Protein | Antibody | cDNA Clone | ELISA Kit)

All BTN2A2 reagents are produced in house and quality controlled, including 13 BTN2A2 Gene, 1 BTN2A2 qPCR. All BTN2A2 reagents are ready to use.

BTN2A2 cDNA Clone (13)

BC017497

BTN2A2 qPCR Primer (1)

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BTN2A2 Related Research Area

BTN2A2 Background

The human and mouse genes encoding butyrophilin-2A2 (BTN2A2) are regulated by the class II trans-activator and regulatory factor X, two transcription factors dedicated to major histocompatibility complex class II expression, suggesting a role in T cell immunity. To address this, Btn2a2-deficient mice are generated. Btn2a2−/− mice exhibited enhanced effector CD4+ and CD8+ T cell responses, impaired CD4+ regulatory T cell induction, potentiated antitumor responses, and exacerbated experimental autoimmune encephalomyelitis. Altered immune responses were attributed to Btn2a2 deficiency in antigen-presenting cells rather than T cells or nonhematopoietic cells. These results provide the first genetic evidence that BTN2A2 is a co-inhibitory molecule that modulates T cell–mediated immunity.

BTN2A2 References

  • Sarter K, Leimgruber E, Gobet F, et al. Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes. The Journal of Experimental Medicine. 2016;213(2):177-187.