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CD47  Protéine

All CD47 Reagents

Hôte d’expression: Human Cells  
  • Slide 1
12283-HCCH-100
12283-HCCH-50
100 µg 
50 µg 
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Hôte d’expression: Human Cells  
  • Slide 1
12283-H02H-50
12283-H02H-100
50 µg 
100 µg 
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Hôte d’expression: Human Cells  
  • Slide 1
57231-M08H-200
57231-M08H-50
200 µg 
50 µg 
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Hôte d’expression: Human Cells  
  • Slide 1
80305-R02H-50
80305-R02H-100
50 µg 
100 µg 
Add to Cart
Hôte d’expression: Human Cells  
  • Slide 1
80305-R08H-50
80305-R08H-100
50 µg 
100 µg 
Add to Cart

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CD47 Voies apparentées

    CD47 Récapitulatif et informations sur les protéines

    CD47 Fond

    Résumé du gène: CD47 gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. CD47 gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for CD47 gene. [provided by RefSeq, Jul 2010]
    General information above from NCBI
    Structure de sous-unités: Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2.
    Localisation subcellulaire: Cell membrane; Multi-pass membrane protein.
    Spécificité tissulaire: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.
    Similarité de séquence: Contains 1 Ig-like V-type (immunoglobulin-like) domain.C
    General information above from UniProt

    CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus.

    CD47 Autre dénomination

    IAP,OA3,MER6, [homo-sapiens]
    antigen identified by monoclonal antibody 1D8,antigenic surface determinant protein OA3,CD47 antigen (Rh-related antigen,CD47 glycoprotein,IAP,integrin associated protein,integrin-associated signal transducer,integrin-associated signal transducer),leukocyte surface antigen CD47,MER6,OA3,Rh-related antigen, [human]
    9130415E20Rik,AA407862,AI848868,AW108519,B430305P08Rik,IAP,integrin-associated protein,Itgp,leukocyte surface antigen CD47,Rh-related antigen, [mouse]
    IAP,Itgp,AA407862,AI848868,AW108519,9130415E20Rik,B430305P08Rik, [mus-musculus]

    CD47 Études apparentées

  • Brown EJ, et al. (2001) Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 11(3): 130-5.
  • Oldenborg PA. (2004) Role of CD47 in erythroid cells and in autoimmunity. Leuk Lymphoma. 45(7): 1319-27.
  • Kaczorowski DJ, et al. (2007) Targeting CD47: NO limit on therapeutic potential. Circ Res. 100(5): 602-3.
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