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CLPS / Colipase Anticorps, Anticorps polyclonaux de lapin, Antigen Affinity Purified

Fiche techniqueCommentairesProduits apparentésProtocoles
Human CLPS Informations sur les produits relatifs aux anticorps
Immunogène:Recombinant Human CLPS / Colipase protein (Catalog#13631-H08B)
Clone ID:
Type d’Ig:Rabbit IgG
Concentration:
Endotoxine:
Tampon:0.2 μm filtered solution in PBS with 5% trehalose
Préparation d'anticorps:Produced in rabbits immunized with purified, recombinant Human CLPS / Colipase (rh CLPS / Colipase; Catalog#13631-H08B; P04118; Met1-Gln112). CLPS / Colipase specific IgG was purified by Human CLPS / Colipase affinity chromatography.
Human CLPS Guide d’utilisation des anticorps
Spécificité:Human CLPS / Colipase
Applications recommandées:ELISA, IHC-P

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CLPS / Colipase. The detection limit for Human CLPS / Colipase is approximately 0.039 ng/well.

IHC-P: 0.1-2 μg/mL

Stockage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human CLPS Antibody IHC Application Image
CLPS / Colipase Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Cliquer pour agrandir l’image]
Caption:
Immunochemical staining of human CLPS in human pancreas with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to pancreatic acinus.
Other CLPS Antibody Products
CLPS / Colipase Fond

Colipase belongs to the colipase family. Structural studies of the complex and of colipase alone have revealed the functionality of its architecture. It is a small protein with five conserved disulphide bonds. Structural analogies have been recognised between a developmental protein, the pancreatic lipase C-terminal domain, the N-terminal domains of lipoxygenases and the C-terminal domain of alpha-toxin. Colipase can only be detected in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Colipase allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Colipase is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilising as active conformation and considerably increasing the overall hydrophobic binding site.

Human CLPS / Colipase Références
  • Davis RC, et al. (1991) Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. Genomics. 10(1):262-5.
  • Lowe ME. (1997) Structure and function of pancreatic lipase and colipase. Annu Rev Nutr. 17: 141-58.
  • Verger R, et al. (1999) Colipase: structure and interaction with pancreatic lipase. Biochim Biophys Acta. 1441(2-3):173-84.
  • Product nameProduct name
    Size / Price
    Catalogue : 13631-RP02-50
    Prix catalogue : 
    Prix :      (You Save: )
    Taille :
    50 µg
    100 µg
    200 µg
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    DisponibilitéIn Stock
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