Anti-Cyclin A1 Antibody

Cat: 11013-RP01

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Anti-Cyclin A1 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-Cyclin A1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Cyclin A1
Immunogen
Recombinant Human Cyclin A1 / CCNA1 protein (Catalog#11013-H07B)
Preparation
Produced in rabbits immunized with purified, recombinant Human Cyclin A1 / CCNA1 (rh Cyclin A1 / CCNA1; Catalog#11013-H07B; NP_003905.1; Met 1-Gln 465). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Anti-Cyclin A1 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Cyclin A1 Antibody Alternative Names

Anti-CT146 Antibody

Cyclin A1 Background Information

Cyclin A1 is a member of the highly conserved cyclin family that is characterized by a dramatic periodicity in protein abundance, and belongs to the A-type cyclin subfamily. The mammalian A-type cyclin family consists of two members: cyclin A1 and cyclin A2. Different cyclins exhibit distinct expression. Cyclin A1 is expressed in mice exclusively in the germ cell lineage and high rate of cyclinA1 is found in human testis and certain myeloid leukaemia cells. Cyclin A1 is primarily function in the control of meiosis. It serves as regulator subunits binding to cyclin-dependent kinase 1 (Cdk1) and cyclin-dependent kinase 2 (Cdk2), which give two different kinase activities, one appearing in S phase, the other in G2. Through this, cyclin A1 operate the entry and progression in cell cycle. High frequency of cyclin A1 overexpression has been observed in acute myelocytic leukemias, especially those that are at the promyelocyte and myeloblast stages of development.
Full Name
cyclin A1
References
  • Yang R, et al. (1999) Functions of Cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Molecular and Cellular biology. 19 (3): 2400-7.
  • Yang R, et al. (1999) Cyclin A1 expression in leukemia and normal hematopoietic cells. Blood. 93 (6): 2067-74.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Cyclin A1 Antibody Mouse Monoclonal WB,ELISA,ICC/IF,IF 11013-MM02
    Anti-Cyclin A1 Antibody Rabbit Polyclonal WB,ELISA,IP 11013-T52
    Anti-Cyclin A1 Antibody Mouse Monoclonal FCM,ICC/IF,IF 11013-MM06
    Anti-Cyclin A1 Antibody Mouse Monoclonal IHC-P 11013-MM01
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