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FGFR4 / FGF Receptor 4 Anticorps, Anticorps polyclonaux de lapin, Antigen Affinity Purified

Fiche techniqueCommentairesProduits apparentésProtocoles
Rat FGFR4 Informations sur les produits relatifs aux anticorps
Immunogène:Recombinant Rat FGFR4 / FGF Receptor 4 protein (Catalog#80093-R08H)
Clone ID:
Type d’Ig:Rabbit IgG
Concentration:
Endotoxine:
Tampon:0.2 μm filtered solution in PBS
Préparation d'anticorps:Produced in rabbits immunized with purified, recombinant Rat FGFR4 / FGF Receptor 4 (rR FGFR4 / FGF Receptor 4; Catalog#80093-R08H; Q498D6; Met1-Asp367). FGFR4 / FGF Receptor 4 specific IgG was purified by Rat FGFR4 / FGF Receptor 4 affinity chromatography.
Rat FGFR4 Antibody IHC Application Image
FGFR4 / FGF Receptor 4 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of rat FGFR4 in rat intestine with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
FGFR4 / FGF Receptor 4 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of rat FGFR4 in rat stomach with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
Other FGFR4 Antibody Products
FGFR4/CD334 Fond

Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR4/CD334 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4/CD334 preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4/CD334 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4/CD334. Mutations in FGFR4/CD334 lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

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Rat FGFR4/CD334 Références
  • Hart KC, et al. (2000) Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene. 19(29): 3309-20.
  • Xie MH, et al. (1999) FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. Cytokine. 11(10): 729-35.
  • Yu C, et al. (2000) Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J Biol Chem. 275(20): 15482-9.
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