HER3 / ERBB3 (Protein | Antibody | cDNA Clone | ELISA Kit)

All HER3 / ERBB3 reagents are produced in house and quality controlled, including 23 HER3 / ERBB3 Antibody, 4 HER3 / ERBB3 ELISA, 39 HER3 / ERBB3 Gene, 1 HER3 / ERBB3 IP Kit, 11 HER3 / ERBB3 Lysate, 12 HER3 / ERBB3 Protein, 2 HER3 / ERBB3 qPCR. All HER3 / ERBB3 reagents are ready to use.

All HER3 / ERBB3 Reagents

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HER3 / ERBB3 Background

ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

HER3 / ERBB3 References

  • Kraus M.H., et al.,(1989), Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. U.S.A. 86:9193-9197.
  • Plowman G.D., et al., (1990), Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.Proc. Natl. Acad. Sci. U.S.A. 87:4905-4909.
  • Katoh M., et al.,(1993), c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase.Biochem. Biophys. Res. Commun. 192:1189-1197.