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Humain VCAM1/VCAM-1/CD106 transcript variant 1 expression plasmide de Gène l'ADNc ORF clone, N-His Marqueur

Fiche techniqueCommentairesProduits apparentésProtocoles
Human VCAM1 Informations sur les produits clonés de cDNA
Gene_bank_ref_id:NM_001078.2
Taille du ADNc:2220bp
Description du ADNc:Full length Clone DNA of Homo sapiens vascular cell adhesion molecule 1, transcript variant 1 with N terminal His tag.
Synonyme du gène:VCAM1, CD106, MGC99561, INCAM-100, DKFZp779G2333
Espèces:Human
Vecteur:pCMV3-SP-N-His
Plasmid:
Site de restriction:
Séquence du marqueur:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Description de la séquence:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Stockage:The lyophilized plasmid can be stored at room temperature for three months.
His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.

Humain VCAM1/VCAM-1/CD106 transcript variant 1 expression plasmide de Gène l'ADNc ORF clone, N-His Marqueur on other vectors
Humain VCAM1/VCAM-1/CD106 transcript variant 1 expression plasmide de Gène l'ADNc ORF clone, C-GFPSpark MarqueurHG10113-ACGCHF290
Humain VCAM1/VCAM-1/CD106 transcript variant 1 expression plasmide de Gène l'ADNc ORF clone, C-OFPSpark MarqueurHG10113-ACRCHF290
Humain VCAM1/VCAM-1/CD106 transcript variant 1 expression plasmide de Gène l'ADNc ORF clone, C-Flag MarqueurHG10113-CFCHF260
Humain VCAM1/VCAM-1/CD106 transcript variant 1 expression plasmide de Gène l'ADNc ORF clone, C-His MarqueurHG10113-CHCHF260
Humain VCAM1/VCAM-1/CD106 transcript variant 1 expression plasmide de Gène l'ADNc ORF clone, C-Myc MarqueurHG10113-CMCHF260
Humain VCAM1/VCAM-1/CD106 transcript variant 1 expression plasmide de Gène l'ADNc ORF clone, C-HA MarqueurHG10113-CYCHF260
Humain VCAM1/VCAM-1/CD106 transcript variant 1 Gène ADNc clone le vecteur de clonageHG10113-MCHF90
Humain VCAM1/VCAM-1/CD106 transcript variant 1 expression plasmide de Gène l'ADNc ORF cloneHG10113-M-NCHF260
Humain VCAM1/VCAM-1/CD106 transcript variant 1 expression plasmide de Gène l'ADNc ORF clone, N-Flag MarqueurHG10113-NFCHF260
Humain VCAM1/VCAM-1/CD106 transcript variant 1 expression plasmide de Gène l'ADNc ORF clone, N-His MarqueurHG10113-NHCHF260
Humain VCAM1/VCAM-1/CD106 transcript variant 1 expression plasmide de Gène l'ADNc ORF clone, N-Myc MarqueurHG10113-NMCHF260
Humain VCAM1/VCAM-1/CD106 transcript variant 1 expression plasmide de Gène l'ADNc ORF clone, N-HA MarqueurHG10113-NYCHF260
Humain VCAM1/VCAM-1/CD106 transcript variant 1 expression plasmide de Gène l'ADNc ORF cloneHG10113-UTCHF260
 En savoir plus sur les vecteurs d'expression
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Fond

Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.

Références
  • Cook-Mills JM. (2002) VCAM-1 signals during lymphocyte migration: role of reactive oxygen species. Mol Immunol. 39(9): 499-508.
  • Preiss DJ, et al. (2007) Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis? Int J Clin Pract. 61(4): 697-701.
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