|Fiche technique||Commentaires||Produits apparentés||Protocoles|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human CNTN5 ORF mammalian expression plasmid, C-GFPSpark tag||HG10513-ACG|
|Human CNTN5 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10513-ACR|
|Human CNTN5 ORF mammalian expression plasmid, C-Flag tag||HG10513-CF|
|Human CNTN5 ORF mammalian expression plasmid, C-His tag||HG10513-CH|
|Human CNTN5 ORF mammalian expression plasmid, C-Myc tag||HG10513-CM|
|Human CNTN5 ORF mammalian expression plasmid, C-HA tag||HG10513-CY|
|人 CNTN5 基因全长ORF克隆||HG10513-M|
|Human CNTN5 ORF mammalian expression plasmid, Flag tag||HG10513-M-F|
|Human CNTN5 ORF mammalian expression plasmid, N-Flag tag||HG10513-NF|
|Human CNTN5 ORF mammalian expression plasmid, N-His tag||HG10513-NH|
|Human CNTN5 ORF mammalian expression plasmid, N-Myc tag||HG10513-NM|
|Human CNTN5 ORF mammalian expression plasmid, N-HA tag||HG10513-NY|
|Human CNTN5 natural ORF mammalian expression plasmid||HG10513-UT|
|En savoir plus sur les vecteurs d'expression|
Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed mainly in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2(TAG-1), Contactin-3(BIG-1), BIG-2, Contactin-5(NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. In contrast, the function of the other four members of this subgroup remained unknown until recently. Contactin-5, also known as NB-2, is one of the neural recognition molecules in the contactin subgroup. Contactin-5 is expressed in brain and kidney and at very low level in placenta. In brain, Contactin-5 is highly expressed in the occipital lobe, amygdala, cerebral cortex, frontal lobe, thalamus and temporal lobe. Mice deficient in the Contactin-5 gene exhibit aberrant responses to acoustic stimuli. Contactin-5 may play a role in maturation of glutamatergic synapses in the brainstem during the final stages of auditory development. Contactin-5 gene may contribute to human neurological disorders.