SR-BI cDNA ORF Clone, Human, untagged General Information
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 501C/T,1050T/C not causing the amino acid variation.
Full length Clone DNA of Human scavenger receptor class B, member 1.
Enhanced CMV promoter
KpnI + XbaI(6.1kb+1.53kb)
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
SR-BI cDNA ORF Clone, Human, untagged Validated Images
SR-BI cDNA ORF Clone, Human, untagged Alternative Names
CD36L1 cDNA ORF Clone, Human;CLA-1 cDNA ORF Clone, Human;CLA1 cDNA ORF Clone, Human;HDLQTL6 cDNA ORF Clone, Human;SR-BI cDNA ORF Clone, Human;SRB1 cDNA ORF Clone, Human
SR-BI Background Information
Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane. SCARB1 is proposed as a receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells, and is involved in a wide variety of physilogical processes. As a key component in the reverse cholesterol transport pathway, SCARB1 binds high density lipoproteins (HDLs) and mediates selective cholesterol uptake by a mechanism distinct from the LDL pathway. High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SCARB1 may thus serve as a useful marker that predicts variation in baseline lipid levels and postprandial lipid response. The mouse SCARB1 has been shown to exert actions in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
scavenger receptor class B, member 1
Murao, K. et al., 1997, J. Biol. Chem. 272(28): 17551-17557. Ikemoto, M. et al., 2000, Proc. Natl. Acad. Sci. U.S.A. 97 (12): 6538-6543. Husemann, J. et al., 2001, Am. J. Pathol. 158 (3): 825-832. Williams, D.L. et al., 2001, Endocr. Res. 26 (4): 639-651. Bulte, B. S. et al., 2002, J. Biol. Chem. 277 (39): 36092-36099. Duncan, K.G. et al., 2002, Biochem. Biophys. Res. Commun. 292 (4): 1017-1022.