The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
STK40 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
STK40 cDNA ORF Clone, Human, C-Myc tag: Alternative Names
SgK495 cDNA ORF Clone, Human; SHIK cDNA ORF Clone, Human
STK40 Background Information
STK4 localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk4 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk4 is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse ESCs. Interestingly, cells overexpressing Stk4 exclusively contribute to the ExEn layer of chimeric embryos when injected into host blastocysts. In contrast, deletion of Stk4 in ESCs markedly reduces ExEn differentiation in vitro. STK4 has a central serine/threonine protein kinase domain and is homologous to TRB-3, a protein that regulates activation of MAP kinases and inhibits NFκB-mediated gene transcription. Similarly, overexpression of STK4 inhibits NFκB activation triggered by TNF and also inhibits p53-mediated transcription. There are four named isoforms of STK4 that are produced as a result of alternative splicing.
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