Commande rapide

Text Size:AAA

IL-1R1 / CD121a Anticorps, Anticorps monoclonaux de lapin

Fiche techniqueCommentairesProduits apparentésProtocoles
Rat IL1R1 Informations sur les produits relatifs aux anticorps
Immunogène:Recombinant Rat IL-1R1 / CD121a protein (Catalog#80028-R08H)
Clone ID:007
Type d’Ig:Rabbit IgG
Concentration:
Endotoxine:
Tampon:0.2 μm filtered solution in PBS with 5% trehalose
Préparation d'anticorps:This antibody was obtained from a rabbit immunized with purified, recombinant Rat IL-1R1 / CD121a (rR IL-1R1 / CD121a; Catalog#80028-R08H; NP_037255.3; Met1-Lys352).
Rat IL1R1 Guide d’utilisation des anticorps
Spécificité:Rat IL-1R1 / CD121a
Has cross-reactivity in ELISA with
Mouse IL1R1
No cross-reactivity in ELISA with
Human IL1R1
Human IL1R3
Human IL1R8
Human IL1R2
Human IL18R1
Applications recommandées:ELISA

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat IL1R1. The detection limit for Rat IL1R1 is approximately 0.00245 ng/well.

Stockage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other IL1R1 Antibody Products
IL1R1/IL-1R1/IL-1 RI Fond

Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.

Rat IL1R1/IL-1R1/IL-1 RI Références
  • Dale M, et al. (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177-9.
  • Joos L, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.". Thorax 56 (11): 863-6.
  • Vigers GP, et al. (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.". Nature 386 (6621): 190-4.
  • Product nameProduct name
    Size / Price
    Catalogue : 80028-R007-50
    Prix catalogue : 
    Prix :      (You Save: )
    Taille :
    50 µg
    100 µg
    Quantité :+-
    DisponibilitéIn Stock
    Bulk Discount RequiryAjouter au panier
    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Veuillez noter : Tous les produits sont « DESTINÉS À LA RECHERCHE UNIQUEMENT ET NE SONT PAS PRÉVUS POUR ÊTRE UTILISÉS À DES FINS DE DIAGNOSTIC OU THÉRAPEUTIQUES »