Her2 / ERBB2 cDNA ORF Clone, Mouse, N-HA tag General Information
Identical with the Gene Bank Ref. ID sequence.
Full length Clone DNA of Mouse v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) with N terminal HA tag.
Enhanced CMV promoter
HindIII + NotI(6kb+3.8kb)
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
Her2 / ERBB2 cDNA ORF Clone, Mouse, N-HA tag Validated Images
Her2 / ERBB2 cDNA ORF Clone, Mouse, N-HA tag Alternative Names
c-erbB2 cDNA ORF Clone, Mouse;c-neu cDNA ORF Clone, Mouse;Erbb-2 cDNA ORF Clone, Mouse;HER-2 cDNA ORF Clone, Mouse;HER2 cDNA ORF Clone, Mouse;l11Jus8 cDNA ORF Clone, Mouse;mKIAA3023 cDNA ORF Clone, Mouse;Neu cDNA ORF Clone, Mouse
Her2 / ERBB2 Background Information
Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
erb-b2 receptor tyrosine kinase 2
Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.