IL-15 cDNA ORF Clone, Mouse, N-HA tag

The protein encoded by IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.

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interleukin 15

• Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory Cytokines & Chemoki and Receptors>>Common gamma Chain Receptor Family
• Immunology>>Innate Immunity>>Cytokine>>Interleukins
• Developmental Biology>>Metabolism>>Types of disease>>Metabolism in Obesity
• Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)
• Cardiovascular>>Angiogenesis>>Cytokine & Receptor>>Interleukin & Receptor>>Other Interleukin & Receptor>>Other Interleukin
• Stem Cells>>Stem Cell Growth Factors,Chemokines and Cytokines>>other stem cell-related Growth Factors, Chemokines and Cytokines
• Cancer>>Signal Transduction>>Jak/STAT Signaling>>Receptors in the Jak/STAT Pathway
• Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory Disorders Therapeutic Targets>>Rheumatoid arthritis Therapeutic Targets

• Mongini PKA, Gupta R, Boyle E, et al. TLR-9 and IL-15 synergy promotes the in vitro clonal expansion of chronic lymphocytic leukemia B cells. Journal of immunology (Baltimore, Md : 1950). 2015;195(3):901-923.