Pre-mRNA-processing factor 19 homolog or PRPF19, is an important component in human spliceosome machinery. Human PRPF19 contains a WD4 repeats domain at its C-terminus, which is also conserved in yeast. PRPF19 is involved in many cellular events including pre-mRNA processing and DNA damage response. PRPF19 is known to be a critical component of the eukaryotic spliceosomal machinery and DNA damage repair system, the deregulation of which leads to many disease conditions. In many human cancers, PRP19 expression is upregulated.
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