Anti-Reg3A Antibody

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Anti-Reg3A Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-Reg3A Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Reg3A
No cross-reactivity in ELISA with
Human REG3G
Mouse REG3A
Human REG1B
Immunogen
Recombinant Human REG3A protein (Catalog#11235-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human REG3A (rh REG3A; Catalog#11235-H08H; Q06141-1; Met 1-Asp 175).
Source
Monoclonal Rabbit IgG Clone #019
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Reg3A Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Reg3A Antibody (Rabbit Monoclonal antibody) Images

Immunochemical staining of human REG3A in human small intestine with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunochemical staining of human REG3A in human pancreatic carcinoma with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).

Anti-Reg3A Antibody: Alternative Names

Anti-HIP Antibody; Anti-HIP/PAP Antibody; Anti-INGAP Antibody; Anti-PAP Antibody; Anti-PAP-H Antibody; Anti-PAP1 Antibody; Anti-PBCGF Antibody; Anti-REG-III Antibody; Anti-REG3 Antibody; Anti-REG3A Antibody; Anti-REG3V Antibody

Reg3A Background Information

Regenerating islet-derived protein 3-alpha, also known as Regenerating islet-derived protein III-alpha, REG-3-alpha, REG3A, and HIP, is secreted protein which contains one C-type lectin domain. REG3A is constitutively expressed in intestine, and is a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It is overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis. REG3A and REG1A proteins are both involved in liver and pancreatic regeneration and proliferation. REG3A is also a stress protein involved in the control of bacterial proliferation. REG3A is down-regulated in most primary human gastric cancer cells, and might be useful in the diagnosis of gastric cancer. Additionally, REG3A is a target of beta-catenin signaling in Huh7 hepatoma cells. The REG1A and REG3A are downstream targets of the Wnt pathway during liver tumorigenesis.
Full Name
regenerating family member 3 alpha
References
  • Cavard C, et al. (2006) Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primary liver tumors with beta-catenin mutations. Oncogene. 25(4): 599-608.
  • Choi B, et al. (2007) Downregulation of regenerating islet-derived 3 alpha (REG3A) in primary human gastric adenocarcinomas. Exp Mol Med. 39(6): 796-804.
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