|Fiche technique||Commentaires||Produits apparentés||Protocoles|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat SLAMF1 ORF mammalian expression plasmid, C-GFPSpark tag||RG80349-ACG|
|Rat SLAMF1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80349-ACR|
|Rat SLAMF1 ORF mammalian expression plasmid, C-Flag tag||RG80349-CF|
|Rat SLAMF1 ORF mammalian expression plasmid, C-His tag||RG80349-CH|
|Rat SLAMF1 ORF mammalian expression plasmid, C-Myc tag||RG80349-CM|
|Rat SLAMF1 ORF mammalian expression plasmid, C-HA tag||RG80349-CY|
|Rat SLAMF1 Gene cDNA clone plasmid||RG80349-G|
|Rat SLAMF1 ORF mammalian expression plasmid, N-Flag tag||RG80349-NF|
|Rat SLAMF1 ORF mammalian expression plasmid, N-His tag||RG80349-NH|
|Rat SLAMF1 ORF mammalian expression plasmid, N-Myc tag||RG80349-NM|
|Rat SLAMF1 ORF mammalian expression plasmid, N-HA tag||RG80349-NY|
|Rat SLAMF1 natural ORF mammalian expression plasmid||RG80349-UT|
|En savoir plus sur les vecteurs d'expression|
CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD150 receptor is expressed on thymocytes, activated and memory T cells, B cells, platelets, natural killer T cells, and mature dendritic cells, and is also detected on tumor cells of Hodgkin's lymphoma (HL) and diffuse large B-cell lymphoma with an activated B cell phenotype. Additionally, it is the immune cell receptor for measles virus (MV). As a self-ligand, CD150 performs diverse immunologic functions including T/B-cell costimulation, induction of IFN-&gamma in Th1 T-cell clones, redirection of Th2 clones to a Th1 or Th0 phenotype, and inhibition of apoptosis in B cells. Furthermore, CD150 was shown to be the second receptor for measles virus in addition to CD46, and the distribution of SLAM on various cell lines is consistent with their susceptibility to clinical isolates of measles virus.