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S100A16 Anticorps, Anticorps monoclonaux de lapin

    Fiche techniqueCommentairesProduits apparentésProtocoles
    Humain S100A16 Informations sur les produits relatifs aux anticorps
    Immunogène:Recombinant Human S100A16 protein (Catalog#11137-HNAE)
    Clone ID:140
    Type d’Ig:Rabbit IgG
    Concentration:
    Endotoxine:
    Tampon:0.2 μm filtered solution in PBS with 5% trehalose
    Préparation d'anticorps:This antibody was obtained from a rabbit immunized with purified, recombinant Human S100A16 (rh S100A16; Catalog#11137-HNAE; Q96FQ6; Met1-Ser103).
    Other S100A16 Antibody Products
    S100A16 Fond

    S100A16 is a member of S100 protein super family that carries calcium-binding EF-hand motifs. S100 proteins are cell- and tissue-specific and are involved in many intra- and extracellular processes through interacting with specific target proteins. S100A16 expression was found to be astrocyte-specific. The S100A16 protein was found to accumulate within nucleoli and to translocate to the cytoplasm in response to Ca(2+) stimulation. The homodimeric structure of human S100A16 in the apo state has been obtained both in the solid state and in solution, resulting in good agreement between the structures with the exception of two loop regions. The homodimeric solution structure of human S100A16 was also calculated in the calcium(II)-bound form. Differently from most S100 proteins, the conformational rearrangement upon calcium binding is minor. Immunoprecipitation analysis revealed that S100A16 could physically interact with tumor suppressor protein p53, also a known inhibitor of adipogenesis. Overexpression or RNA interference-initiated reduction of S100A16 led to the inhibition or activation of the expression of p53-responsive genes, respectively. S100A16 protein is a novel adipogenesis-promoting factor.

    Humain S100A16 Références
  • Sturchler E, et al. (2006) S100A16, a novel calcium-binding protein of the EF-hand superfamily. J Biol Chem. 281(50): 38905-17.
  • Liu Y, et al. (2011) Identification of S100A16 as a Novel Adipogenesis Promoting Factor in 3T3-L1 Cells. Endocrinology. 152(3): 903-11.
  • Babini E, et al. (2011) Structural characterization of human S100A16, a low-affinity calcium binder. J Biol Inorg Chem. 16(2): 243-56.
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    Size / Price
    Catalogue : 11137-R140-50
    Prix catalogue : 
    Prix :      (You Save: )
    Taille :
    50 µg
    100 µg
    Quantité :+-
    DisponibilitéIn Stock
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    Datasheet & Documentation

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