SOCS1 cDNA ORF Clone in Cloning Vector, Human

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SOCS1 cDNA ORF Clone in Cloning Vector, Human: General Information

Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
636 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human suppressor of cytokine signaling 1.
Plasmid
Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

SOCS1 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

SOCS1 cDNA ORF Clone in Cloning Vector, Human: Alternative Names

CIS1 cDNA ORF Clone, Human; CISH1 cDNA ORF Clone, Human; JAB cDNA ORF Clone, Human; SOCS-1 cDNA ORF Clone, Human; SSI-1 cDNA ORF Clone, Human; SSI1 cDNA ORF Clone, Human; TIP3 cDNA ORF Clone, Human

SOCS1 Background Information

Suppressor of cytokine signaling1 (SOCS1) is a widely recognized tumor suppressor gene. Silencing of SOCS1 expression as a result of promoter methylation is associated with occurrence and development of solid tumors such as liver, cervical and pancreatic cancer. Downregulation of suppressor of cytokine signalling-1 (SOCS1) is one of the vital reasons for JAK1-STAT3 pathway activation in acute myeloid leukaemia (AML). The DCs transduced with SOCS1 gene exhibit as DCregs through negative regulation of JAK2/STAT1 pathway and ameliorated lipopolysaccharide/d-galactosamine induced acute liver failure via inhibition of TLR4 pathway.
Full Name
suppressor of cytokine signaling 1
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