TYR cDNA ORF Clone in Cloning Vector, Human

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TYR cDNA ORF Clone in Cloning Vector, Human: General Information

Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
1134 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human tyrosinase (oculocutaneous albinism IA).
Plasmid
Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

TYR cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

TYR cDNA ORF Clone in Cloning Vector, Human: Alternative Names

ATN cDNA ORF Clone, Human; CMM8 cDNA ORF Clone, Human; OCA1 cDNA ORF Clone, Human; OCA1A cDNA ORF Clone, Human; OCAIA cDNA ORF Clone, Human; SHEP3 cDNA ORF Clone, Human

TYR Background Information

TYR is a melanosomal membrane-bound glycoprotein with a native molecular weight of 55kD, which increases to 65-75kD following post-translational modification at six potential N-glycosylation sites as it traffics to the mature melanosome. It is the key enzyme for pigmentation that catalyzes the oxidation of its substrates tyrosine and DOPA to form the intermediate DOPAquinone.
Full Name
tyrosinase
References
  • Jagirdar K, Smit DJ, Ainger SA, et al. Molecular analysis of common polymorphisms within the human Tyrosinase locus and genetic association with pigmentation traits. Pigment cell & melanoma research. 2014;27(4):552-564.
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