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aFGF / FGF1  Protéine

All aFGF Reagents

Description du produit: Active  
Hôte d’expression: E. coli  
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10013-HNAE-10
10013-HNAE-50
10013-HNAE-100
10013-HNAE-500
10013-HNAE-1
10 µg 
50 µg 
100 µg 
500 µg 
1 mg 
Add to Cart
Description du produit: Active  
Hôte d’expression: E. coli  
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50179-MNAE-50
50179-MNAE-100
50179-MNAE-500
50179-MNAE-1
50179-MNAE-10
50 µg 
100 µg 
500 µg 
1 mg 
10 µg 
Add to Cart
Description du produit: Active  
Hôte d’expression: E. coli  
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90062-CNAE-50
90062-CNAE-100
90062-CNAE-10
50 µg 
100 µg 
10 µg 
Add to Cart
Hôte d’expression: E. coli  
  • Slide 1
  • Slide 1
70039-DNAE-10
70039-DNAE-50
70039-DNAE-100
10 µg 
50 µg 
100 µg 
Add to Cart

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aFGF / FGF1 Voies apparentées

aFGF / FGF1 Récapitulatif et informations sur les protéines

aFGF / FGF1 Fond

Résumé du gène: The protein encoded by FGF1 gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
General information above from NCBI
Structure de sous-unités: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1 (By similarity). Interacts with S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1.
Localisation subcellulaire: Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.
Spécificité tissulaire: Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
Post-traductionnel: In the nucleus, phosphorylated by PKC/PRKCD.
Similarité de séquence: Belongs to the heparin-binding growth factors family.
General information above from UniProt

aFGF, also known as FGF1 and HBGF-1, is a member of the fibroblast growth factor family. The biological activity of aFGF protein is exerted through binding to four high affinity cell surface receptors (FGFR1–4), which results in receptor dimerization and transphosphorylation in the tyrosine kinase domain. aFGF protein shows a wide range of endocrine-like activities. As a multiple function growth factor, this protein is involved in embryo development and tissue repair. Additionally, this protein is considered to function in several important physiological and pathological processes, such as embryonic development, morphogenesis, angiogenesis, wound healing and atheromatosis, carcinogenesis, development, and invasion of cancer.

References

aFGF / FGF1 Autre dénomination

aFGF / FGF1 Études apparentées

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