Kininogen 1: Kininogen 1 Protein | Kininogen 1 Antibody

Kininogen 1 Gene family

Kininogen 1 Background

Kininogen-1, also known as high molecular weight kininogen, williams-Fitzgerald-Flaujeac factor, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, KNG1 and BDK, is a secreted protein which contains three cystatin domains. Kininogen-1 / KNG1 is a protein from the blood coagulation system as well as the kinin-kallikrein system. It is a protein that adsorbs to the surface of biomaterials that come in contact with blood. Kininogen-1 / KNG1 circulates throughout the blood and quickly adsorbs to the material surfaces. Kininogen-1 / KNG1 is one of the early participants of the intrinsic pathway of coagulation, together with Factor XII (Hageman factor) and prekallikrein. Kininogen-1 / KNG1 is one of the kininogens, a class of proteins. As with many other coagulation proteins, the protein was initially named after the patients in whom deficiency was first observed. When the clinical data were combined, it turned out that all patients, in fact, had a deficiency of the same protein. Defects in KNG1 are the cause of high molecular weight kininogen deficiency (HMWK deficiency) which is an autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis.

Reference for Kininogen 1

  • Ohkubo I., et al.,(1984), Isolation of a human cDNA for alpha 2-thiol proteinase inhibitor and its identity with low molecular weight kininogen. Biochemistry 23:5691-5697.
  • Takagaki Y., et al., (1985), Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary structures of two human prekininogens.J. Biol. Chem. 260:8601-8609.
  • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.

Kininogen 1 Protein

Kininogen 1 protein function

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Kininogen 1 protein expression

Tissue specificity

Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.

Kininogen 1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

Kininogen 1 Antibody

There are 11 Kininogen 1 antibodies which are validated in multiple tissues with various applications, including ELISA(Cap), ELISA(Det), ELISA, IHC-P. There are 1 Kininogen 1 antibody for ELISA(Cap), 1 Kininogen 1 antibody for ELISA(Det), 8 Kininogen 1 antibody for ELISA, 1 Kininogen 1 antibody for IHC-P. Among all these Kininogen 1 antibodies, there are 3 anti-Kininogen 1 mouse monoclonal antibodies , 7 anti-Kininogen 1 rabbit polyclonal antibodies , 1 anti-Kininogen 1 rabbit monoclonal antibodies . All the Kininogen 1 anbodies are produced in house and all are in stock. Kininogen 1 antibody customerized service is available.

Kininogen 1 Gene

KNG1 gene / cDNA is a protein-coding gene which located on 3q27.3. The KNG1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.184 organisms have orthologs with human gene KNG1.