CD20 Proteins, Antibodies, cDNA Clones Research Reagents

MS4A1 (Membrane Spanning 4-Domains A1, also known as B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16), located on 11q12.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 33077 Da protein composed of 297 amino acids. This gene encodes a member of the membrane-spanning 4A gene family. Diseases such as Immunodeficiency, Common Variable, 5, and Common Variable Immunodeficiency are associated with MS4A1. The related pathways of MS4A1 include Hematopoietic cell lineage and Hematopoietic Stem Cells and Lineage-specific Markers.

CD20 Protein (5)

    CD20 Antibody (17)

      CD20 cDNA Clone (52)

      NM_021950.3
      NM_007641.5
      XM_004770405.1
      XM_001086364.2

      CD20 Lysate (3)

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        CD20 Background

        CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed in all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections, and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells are usually in the normal range but can be very low.

        CD20 References

        • Tedder TF, et al. (1988) Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci. 85(1): 208-12.
        • Cragg MS, et al. (2005) The biology of CD20 and its potential as a target for mAb therapy. Curr Dir Autoimmun. 8: 140-74..
        • Polyak MJ, et al. (2003) A cholesterol-dependent CD20 epitope detected by the FMC7 antibody. Leukemia. 17(7): 1384-9.

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