interferon-alpha/IFNA5 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IFNA5 (Interferon Alpha 5, also known as INA5; INFA5; Leif G; IFN-alphaG; IFN-alpha-5), located on 9p21.3, is a Protein Coding gene. The gene produces a 21942 Da protein composed of 189 amino acids. IFNA5 belongs to the alpha/beta interferon family. IFNA5 is the only IFNA subtype detected in normal liver, while a mixture of subtypes is observed in the liver tissue of patients with chronic hepatitis C. Diseases such as Hemangioma Of the Lung and Myiasis are associated with IFNA5. The related pathways of IFNA5 include all-trans-retinoic Acid Mediated Apoptosis and Tuberculosis.

All interferon-alpha/IFNA5 Reagents

interferon-alpha/IFNA5 Protein (8)

    interferon-alpha/IFNA5 Antibody (9)

      interferon-alpha/IFNA5 ELISA Kit & Match Antibody ELISA Pair Set (2)

      interferon-alpha/IFNA5 cDNA Clone (39)

      NM_002169.1
      NM_010505.2
      XM_001076062.1

      interferon-alpha/IFNA5 Lysate (5)

        interferon-alpha/IFNA5 Background

        Interferon, alpha 5 (IFNA5) belongs to the alpha/beta interferon family. IFNA5 is the only IFNA subtype detected in normal liver, while a mixture of subtypes is observed in the liver tissue of patients with chronic hepatitis C. Interferons are produced by macrophages, IFN-alpha has antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation.

        interferon-alpha/IFNA5 References

        • Lau JY, et al. (1993) Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C. Lancet. 342(8881): 1208-9.
        • Kessler DS, et al. (1990) Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator. Genes Dev. 4(10): 1753-65.
        • Gutterman JU. Cytokine therapeutics: lessons from interferon alpha. Proc Natl Acad Sci U S A. 91(4): 1198-205.

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