LDLR/LDL Receptor Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

LDLR (Low-Density Lipoprotein Receptor, also known as FH; FHC; FHCL1; LDLCQ2), located on 19p13.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog. The gene produces a 95376 Da protein composed of 860 amino acids. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Diseases such as Hypercholesterolemia, Familial, 1, and Homozygous Familial Hypercholesterolemia are associated with LDLR. The related pathways of LDLR include Lipoprotein metabolism and G-protein signaling Ras family GTPases in kinase cascades (scheme).

LDLR/LDL Receptor Protein (6)

    LDLR/LDL Receptor Antibody (21)

      LDLR/LDL Receptor ELISA Kit & Match Antibody ELISA Pair Set (2)

      LDLR/LDL Receptor cDNA Clone (26)

      NM_000527.3
      NM_010700.2

      LDLR/LDL Receptor Lysate (3)

        LDLR/LDL Receptor Background

        LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low-density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.

        LDLR/LDL Receptor References

        • Yamamoto T, et al. (1984) The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 39(1): 27-38.
        • Mao B, et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 411(6835): 321-5.
        • Pinson KI, et al. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 407(6803): 535-8.

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