Peroxiredoxin 2 Proteins, Antibodies, cDNA Clones Research Reagents

PRDX2 (Peroxiredoxin 2) is a protein coding gene located on human chromosome 19p13.13. PRDX2 is also known as PRP, TSA, PRX2, PTX1, TPX1, NKEFB, PRXII, TDPX1, NKEF-B and HEL-S-2a. The human PRDX2 gene encodes a 21892 Da protein containing 198 amino acids. The PRDX2 protein is ubiquitously expressed in bone marrow, heart and other tissues. Among its related pathways are Folate Metabolism and Neurodegenerative Diseases. PRDX2 is related to oxidoreductase activity and peroxiredoxin activity. PRDX1 is an important paralog of PRDX2 gene. PRDX2 is associated with some diseases, including In Situ Carcinoma and Hemolytic Anemia.

Peroxiredoxin 2 Protein (2)

    Peroxiredoxin 2 Antibody (2)

      Peroxiredoxin 2 cDNA Clone (75)

      Peroxiredoxin 2 Lysate (2)

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        Peroxiredoxin 2 Background

        Peroxiredoxin-2, also known as Natural killer cell-enhancing factor B, NKEF-B, Thiol-specific antioxidant protein, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, PRDX2 and NKEFB, is a cytoplasm protein that belongs to the ahpC / TSA family. Peroxiredoxin-2 / PRDX2 contains one thioredoxin domain. Peroxiredoxin-2 / PRDX2 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system. Peroxiredoxin-2 / PRDX2 is not able to receive electrons from glutaredoxin. It may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin-2 / PRDX2 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. The Peroxiredoxins / Prx are a family of peroxidases that can reduce H2O2 using an electron from thioredoxin (Trx) or other substances. The mammalian Peroxiredoxins / Prx family is divided into six groups (PRDX1,PRDX2, PRDX3, PRDX4, PRDX5, PRDX6) on the basis of homology of amino acid sequences. They are located in the cytosol and play a role in the cell signaling system. All six mammalian peroxiredoxins are expressed in the lung. Peroxiredoxins / Prx is overexpressed in breast cancer tissues to a great extent suggesting that Peroxiredoxins / Prx has a proliferative effect and may be related to cancer development or progression.

        Peroxiredoxin 2 References

        • Cha M.-K., et al., 1995,  Biochem. Biophys. Res. Commun. 217:900-7.
        • Noh,D.Y. et al., 2001, Anticancer Res. 21 (3B): 2085-90.
        • Chevallet M., et al., 2003, J. Biol. Chem. 278:37146-53.
        • Schremmer,B. et al., 2007, Subcell Biochem. 44 :317-44.
        • Gauci S., et al., 2009, Anal. Chem. 81:4493-501.

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