SinommuneTM Multiplex Antigen Microarray

Sino Biological's SinommuneTM is a multiplex assay platform for high-throughput serological studies. The arrays are produced by printing validated recombinant antigens on nitrocellulose-coated slides. Each slide contains multiple pads, each with a single array. The arrays consist of hundreds of antigen spots arranged in a grid. The antigens are pre-printed and adsorbed onto the 3-dimensional topography of the nitrocellulose surface.

These arrays are designed to determine the antibody profile in serum samples, and monitor its changes over time under different circumstances. The arrays are uniquely suitable for epidemiology studies, as they can be used as a serologic surveillance tool to determine the prevalence of the infection during an epidemic. Figure 1 showed the result from a recent jointed study published on Biorxiv. The heat map clearly showed a distinct IgG reactivity towards SARS-CoV-2 in eight convalescent specimens from recovered COVID-19 patients.


Figure 1

*SinommuneTM collection is jointly developed by Sino Biological Inc. and Nanommune Inc. (Irvine, CA), and are exclusively marketed by Sino Biologcal Inc.

 

SinommuneTM Arrays

The SinommuneTM arrays are offered both as standard products and as customized services. Please find the list of the standard arrays, and their detection antigens below:

The SinommuneTM platform offers high throughput and flexibility. The number of antigens on each grid and the number of pads on each slide can both be customized. In addition, the choice of antigens can be made from any available antigens from the ProvirTM viral antigen bank.

*Please note a minimal qty requirement may apply.

Under Development

The SinommuneTM platform offers high throughput and flexibility. The number of antigens on each grid and the number of pads on each slide can both be customized. In addition, the choice of antigens can be made from any available antigens from the ProvirTM viral antigen bank.

*Please note a minimal qty requirement may apply.

 

Assay Procedure

The serum sample will be loaded onto the slide, where the antibodies will bind with the coated antigens. After incubation and washing, the secondary detection is carried out using fluorophore-conjugated anti-isotype antibodies. Following that, the slide can be imaged using regular microarray reader. Please find the detailed protocol here.

 

Assay Service

For customers who wish to source out the experiment, the service is offered by our partner company Nanommune. Please contact us for more details.

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Recombinant Antibody Production