CD23 Protein Overview: Sequence, Structure, Function and Protein Interaction

CD23 Protein Overview

The human leukocyte differentiation antigen CD23 (FCE2) is a key molecule for B-cell activation and growth. It is the low-affinity receptor for IgE. The truncated molecule can be secreted, then functioning as a potent mitogenic growth factor.

CD23 protein name

Recommended name
Low affinity immunoglobulin epsilon Fc receptor
Aliases
CD23, CLEC4J, Fc epsilon receptor II
Alternative name
BLAST-2 C-type lectin domain family 4 member J Fc-epsilon-RII Immunoglobulin E-binding factor Lymphocyte IgE receptor CD_antigen: CD23 Low affinity immunoglobulin epsilon Fc receptor membrane-bound form Low affinity immunoglobulin epsilon Fc receptor soluble form

CD23 Gene family protein

CD23 Protein Sequence

Species Human CD23 protein
Length 321
Mass (Da) 36469
Sequence Human CD23 protein sequence
Species Mouse CD23 protein
Length 331
Mass (Da) 37648
Sequence Mouse CD23 protein sequence
Species
Length
Mass (Da)
Sequence

CD23 Protein Molecular Weight & PI

Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD23 antigen) [Contains: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form] Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-321 Low affinity immunoglobulin epsilon Fc

Molecular weight (Da)

36468.78

Theoretical pI

5.38

CD23 Protein Structure

Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form B)
Deposited
2013-02-11   Released:  2013-08-28
Deposition Author(s)
Dhaliwal, B., Pang, M.O.Y., Sutton, B.J.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.3000 Å
R-Value Free
0.218
R-Value Work
0.191
4J6K From PDB

Human CD23 protein Secondary structure

CD23 Protein Interaction

Recombinant CD23 Protein Feature

CD23 Protein, Human, Recombinant (His Tag)

High Purity
> 96 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

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