FCRN/FCGRT Information: FCRN/FCGRT Protein, FCRN/FCGRT Antibody and FCRN/FCGRT Gene

FCRN/FCGRT Gene family


FCRN/FCGRT protein function

Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7964511, PubMed:10933786). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus (PubMed:7964511). {ECO:0000250|UniProtKB:P13599, ECO:0000269|PubMed:10933786, ECO:0000269|PubMed:7964511}.

FCRN/FCGRT protein expression

Tissue specificity

Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.

FCRN/FCGRT protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)


FCGRT gene / cDNA is a protein-coding gene which located on 19q13.33. The FCGRT gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.116 organisms have orthologs with human gene FCGRT.